If you can afford it, get a ISF professional to come and calibrate your tv for you. It will need running in for about 200 hours before they arrive. The picture out of the box is pretty damm good. Everyone raved about pure mode but I found that too pale and washed out for me. You'll find it has more settings than a nasa space capsule but you will find lots of recommended picture settings on other forums.
I have my 600A set-up very simply and the same way a lot of people do and it works really well (for me anyway).
Blu-ray connected to amp via hdmi
Sky Box connected to amp via hdmi & digital optical cable (to enable Dolby Digital audio)
Amp connected to media receiver (input 4) via HDMI.
As I also have a pioneer amp the amp remote controls it all when I select TV, it changes the picture and audio to the TV and when I select BD it changes the picture and audio to blu-ray.
I have sky picture settings at Auto. So when watching an HD sky program it outputs at 1080i, when watching an SD sky program it outputs at 576. Some people have their sky box to output at 1080i, but personally I find the SD pics look much better at 576.
Anyway , have fun and enjoy.
Pioneer KRP-600A, Pioneer LX08, Pioneer SC-LX81, Sky HD+, Tannoy Revolution Signature DC6T, DC6LCR, Arena Highline 500 Rears, Sunfire HRS-12 Sub, Chord Silver Plus HDMI & Chord Rumour Speaker Cables, Clearer Audio Mains Cables, AV Podium Rack